TTSurv Going through the MultiGene Prospects inside 1000s of Malignancies

Although interventional radiology and radiofrequency ablation should be very carefully performed after pancreaticoduodenectomy or biliary reconstruction, our patient showed a good response to treatment without serious complications.
This report details our experience in treating liver metastasis from a pNET after pancreaticoduodenectomy. The metastasis was successfully treated by radiofrequency ablation combined with transcatheter arterial embolization.
This report details our experience in treating liver metastasis from a pNET after pancreaticoduodenectomy. The metastasis was successfully treated by radiofrequency ablation combined with transcatheter arterial embolization.
Osteoid osteoma is a benign tumor of bone that predominantly affects young age group. It can affect any bone, but lower extremities are more commonly involved more than the upper extremities and it rarely affects the scapular glenoid.
The present case is an 18-year-old female patient who suffered from chronic right forearm and shoulder nocturnal pain for 5 years, which was sometimes relieved by non-steroidal anti-inflammatory drugs intake. Prior to referral to orthopedic clinic, she was diagnosed as a case of a regional pain syndrome, managed by medical treatment without significant improvement. The diagnosis of an inferior glenoid osteoid osteoma was established radiologically. The patient was managed successfully by percutaneous radiofrequency ablation and the pain disappeared gradually after 2 weeks of the procedure.
The presence of lesions in unusual locations along with an atypical medical history could misinterpret and delay the diagnosis. Osteoid osteoma could be difficult to detect with plain radiographs; thus, advanced imaging is crucial if such lesion is suspected.
The scapular glenoid osteoid osteoma should be considered as part of the differential diagnosis of chronic shoulder pain especially if there is no response to initial medical treatment. Awareness of atypical presentations of scapular osteoid osteoma is required to avoid delay in diagnosis and treatment.
The scapular glenoid osteoid osteoma should be considered as part of the differential diagnosis of chronic shoulder pain especially if there is no response to initial medical treatment. Awareness of atypical presentations of scapular osteoid osteoma is required to avoid delay in diagnosis and treatment.
The direct oral anticoagulants (DOAC) have similar half-lives, but the dosing regimen varies between once daily (QD) or twice daily (BID). For some prescribers, the QD regimen improves compliance. Others prefer BID regimens to promote better stability of plasma concentrations, particularly in the event of missed doses. Limited level of evidence provides guidance about the best treatment strategy. The purpose of this study was to compare the treatment effect of QD vs. Oxaliplatin in vitro BID administration of DOACs in major orthopedic surgery (MOS), non-valvular atrial fibrillation (NVAF), venous thromboembolism (VTE), and acute coronary syndrome (ACS).
We conducted a systematic review up to April 2020. We included phase II clinical trials comparing DOAC QD vs BID with same daily dose. We extracted data for the occurrence of major thrombosis (proximal deep vein thrombosis, pulmonary embolism, myocardial infarction, ischemic stroke) and major hemorrhage (ISTH criteria and recommendations of the European Medicines Agency for surgical patients). Relative risks (RR) were combined using a fixed and random effects weighted meta-analysis.
Twelve randomized, controlled, phase II trials were included (10,716 patients), representing 24 dosing regimen comparisons of apixaban, darexaban, edoxaban, rivaroxaban, letaxaban, and dabigatran. There was no difference for major thrombotic event (RR
=1.06, 95%IC 0.86-1.30) nor for major bleeding (RR
=1.02, 95%IC 0.84-1.23) between the BID vs QD regimens, without heterogeneity (I
=0%).
Our study does not support a global difference in term of efficacy and safety of the BID and QD regimens of DOAC in MOS, NVAF, VTE and ACS.
Our study does not support a global difference in term of efficacy and safety of the BID and QD regimens of DOAC in MOS, NVAF, VTE and ACS.The European badger, Meles meles (Carnivora, Mustelidae) is a widespread opportunistic omnivorous mammal. Its food spectrum comprises a wide variety of plants and small animals, occasionally including rodents, such as mice or rats. Considering that rodents are known to play a key role in the life cycle of Trichinella spp., the aims of this study were to investigate the occurrence of these parasites in badgers from Romania and to identify the species. Overall, 61 badgers originating from 14 counties were examined by trichinoscopy and artificial digestion. For species determination, the positive muscle samples, and the larvae recovered from the artificial digestion were used for DNA isolation, and further processed by multiplex PCR. A single badger, originating from Sibiu County, Central Romania, was found positive for Trichinella spp. Five cysts were identified using trichinoscopy four in the diaphragm and one in the foreleg muscles. Artificial digestion revealed an infection rate of 70 larvae/100 g of muscle. The PCR indicated the occurrence of T. britovi, which is the most commonly detected species in wild carnivores in temperate areas. Although T. britovi has previously been reported in Romania, this represents the first report of its occurrence in the European badger in the country. However, the low prevalence indicates a minor reservoir role of this species.East Coast fever (ECF) is an often fatal, economically important cattle disease that predominantly affects eastern, central, and southern Africa. ECF is controlled through vaccination by means of simultaneous injection of oxytetracycline and cryogenically preserved stabilate containing live, disease-causing parasites. Storage and transportation of the stabilate requires liquid nitrogen, a commodity that is commonly unreliable in low-resource settings. Here we show that storage of conventionally prepared stabilate at -80 °C for up to 30 days does not significantly affect its ability to infect cultured peripheral blood mononucleated cells or live cattle, suggesting an alternative cold chain that maintains these temperatures could be used to effectively manage ECF.